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Early studies showed that people on GLP-1s lost quite a bit of lean mass, which some took to mean the loss of muscle

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Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

Cinar R, Iyer MR, Kunos G

3 More recently, a meta-analysis integrating the available trials observed that even doses as low as 80mg twice daily were able to produce significant weight loss as well as reductions in HbA1c