Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis
Physiol Behav 106(3):387393 Drucker DJ (2003) Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis
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Key observations include: Non-competing receptors: GHRH-R and GHS-R1a are distinct receptor systems Additive signaling: Simultaneous activation may produce greater GH release than either pathway alone Somatotroph priming: GHRP activation may enhance responsiveness to GHRH "The combination of GHRH and GHRP stimulates GH release synergistically through separate receptor-mediated mechanisms." Bowers, 2004 Why CJC-1295 + Ipamorelin Specifically