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Baseline measurements found that TNF-alpha and IL-1-beta levels in the APP/PS1 group of mice were much higher than the wild type group of mice

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175 , JC92 (2022)

By activating these receptors in the brains satiety centers (like the area postrema), it promotes feelings of fullness, reduces food intake, and helps stabilize post-meal blood sugar spikes, making it a promising candidate for weight management, particularly in combination with the GLP-1 receptor agonist semaglutide (marketed as CagriSema)

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Pevec D, Novinak T, Bri L, ipo K, Juki I, Stareini M, et al