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Over time, that pooling puts sustained pressure on the vein walls and surrounding tissue, producing the symptoms most people recognize: twisted, rope-like varicose veins, smaller spider veins, persistent leg swelling, aching, skin discoloration, and in advanced cases, open sores called venous ulcers

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In a study targeting the effects of Benadryl and Tagamet, antihistamines were found to block the same receptors from histamine and slow the increase in blood flow to the skin, an effective method to reduce flush

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