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Glymphatic Dysfunction and Perivascular Spaces Enlarged perivascular spaces are increasingly recognized as important markers of CSVD

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This prespecified analysis examined the effects of semaglutide on dual primary endpoints (change in Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score (KCCQ-CSS) and body weight) and confirmatory secondary endpoints (change in 6-minute walk distance (6MWD), hierarchical composite (death, HF events, change in KCCQ-CSS and 6MWD) and change in C-reactive protein (CRP)) across obesity classes IIII (body mass index (BMI) 30.034.9 kg m 2 , 35.039.9 kg m 2 and 40 kg m 2 ) and according to body weight reduction with semaglutide after 52 weeks

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Recent animal research in 2025 explored its role in colitis, showing mucosal healing and reduced inflammation