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T2DM: type 2 diabetes mellitus Outcomes in diabetes mellitus GLP-1, a member of the incretin hormone family secreted in response to nutrient intake, enhances insulin secretion in a glucose-dependent way [72]

11 Whole brain cFos expression in response to semaglutide, MK-801, GLP-1 and GLP-1MK-801

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After 72 weeks, patients who received up to 6 mg of orforglipron averaged a weight loss of 5.5%, those who received 12 mg averaged 7.8%, and those who received 36 mg averaged 10.5%, while the placebo group averaged just 2.2%

Phentermine-topiramate was 10%

doi: 10.1111/bph.12895 107 ZhaoDLiuJWangMZhangXZhouM