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Lingvay I, Catarig AM, Frias JP, et al

Hou Y, Ernst SA, Heidenreich K, Williams JA

However, NADPH homeostasis in cancer cells is maintained through multiple metabolic pathways, including the pentose phosphate pathway, folate metabolism, and malic enzyme activity, making single-pathway inhibition less effective 36

The various mechanisms that are used by these signal regulators in modulating JAKSTAT signaling will be focused on below