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GIP receptor (the 'handle fuel' lever) GIP is short for glucose-dependent insulinotropic polypeptide

High-dose oral semaglutide (Wegovy Tablet) Novo Nordisk have developed a higher-dose version of the semaglutide pill specifically for obesity

and Rybelsus, an oral diabetes medication

GLP-1 Significance in Research and Therapeutics Due to its beneficial effects on glucose control and potential for weight loss, GLP-1 and its analogs have become a focus for the development of therapies for type 2 diabetes and obesity

Nat Rev Endocrinol 8(12):728742

As a result, GLP-1 therapies are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2