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While patents exist, the challenge of proving novelty and non-obviousness for peptides derived from natural sequences can be complex

No significant metabolic contraindications: Active malignancy, uncontrolled insulin resistance, or significant thyroid disease can alter both the risk-benefit calculation and the expected response

GLP-1 medications slow gastric emptying significantly, meaning food and stomach acid stay in the stomach longer

Refrigeration doesn't stop hydrolysis, but it slows it down dramatically, extending the peptide's useful life from mere hours to several weeks

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