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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

contributed to the study conception and design

And the internet loves to speculate whether a woman who loses weight has been on GLP-1s and whether using these medications is taking "the easy way out." Sipes questions whether it's realistic or fair to expect someone on a weight loss journey to be immune to societal pressure

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The participants that started using weight reduction medication during the first year lost on average 11.7% (17.0 kg) and the participants starting after one year lost on average 4.7% (5.8 kg)

In people who are overweight or obese, the SELECT study showed a significant decrease in major adverse cardiovascular events (MACE), including heart attacks, strokes, and cardiovascular deaths