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Further, the GLP-1R antagonist Ex 9-39 eliminated the neuroprotective effects of semaglutide in this study, implying that GLP-1Rs play a key role in these effects

Science 363 , 838845 (2019)

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Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92