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Some of the main causes of low sex drive are: Depression, anxiety, and stress Relationship problems Sexual problems like vaginal dryness and erectile dysfunction Hormonal imbalances Certain medications Excessive use of alcohol Underlying medical conditions like cancer, heart disease, diabetes Treatment options of low sex drive normally depend on the cause

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Gnrh mRNA levels were significantly lower in the DSS-treated mice than in their litter-mate controls, as were those of Kiss1 (Kiss1 regulates Gnrh expression and release via binding its receptor on GnRH neurons: Fig S6)

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