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The glucose effect falls out of the same pharmacology GH-driven lipolysis floods free fatty acids, GH signaling impairs insulin-mediated glucose disposal and raises hepatic output, and GH-induced SOCS proteins can interfere with insulin-receptor signaling

30 Furthermore, a comparative trial of exenatide and liraglutide in T2DM subjects concluded that both incretin mimetics were associated with a significant reduction in body weight when compared to baseline (2.87 kg and 3.24 kg, respectively)

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After a reasonable starting all-atom model was retrieved, residue repacking at a specific position was done with the Rosetta platform to screen for peptides (ITP2) that specifically bind to v -TMD 40 (Fig