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The index single-nucleotide polymorphism (SNP) of the main association was rs10305420 ( P = 2.9 10 10 , reference allele C, effect allele T), which conferred an additional 0.641% BMI loss per T allele, approximately equivalent to an additional 0.76 kg weight loss per allele (95% CI, [1.27, 0.34] kg)

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With both shortages now resolved, that pathway is no longer available for these medications