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Consequently, our study was granted a letter of waiver by our institutions Institutional Review Board (IRB) because it does not fall under the category of human subject research

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However, if you are using a high-quality liposomal delivery system, once a day is typically sufficient

Jan 28 2021;42(1):77-96

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Kojic acid and hydroquinone proved to be useful hypopigmentation agents, with hydroquinone performing with superior results in the Melasma Area Severity Index (MASI)