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The neutrophils molecules are related to endothelial adhesion, maturation and migration [43, 44]

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Epoxidation of the 9, 10-alkene linkage by THC is the proposed mechanism of DNA damage [325], and DNA alkylatation by epoxides simultaneously generates ROS [324, 326]

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Specifically, changes in gut microbiota diversity can affect epidermal differentiation pathways, immune regulation, inflammatory signaling, and barrier integrity mediated by microbial metabolites, ultimately destabilising skin immune homeostasis [93]