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The endogenous source of ROS in erythrocytes is the autoxidation of Hb [11, 12]

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Melanoma differentiation-associated protein 5 (MDA5) binds to long-stranded mt-dsRNA, recruits mitochondrial antiviral-signaling (MAVS) proteins to mitochondria-associated endoplasmic reticulum membranes (MAMs), activates the NF-B pathway, and induces the expression IFN-, IL-15, and IFN-1