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The LEADER trial enrolled patients with T2DM and high cardiovascular risk, defined as established CVD (81%) or age 60 years with at least one risk factor, and showed that liraglutide significantly reduced the incidence of 3-point major adverse cardiovascular events (MACE) (i.e., CV death, non-fatal myocardial infarction, non-fatal stroke) by 13% compared to placebo (HR 0.87
They form a vicious cycle
Despite the biological plausibility of vitamin A in supporting immune function, the findings do not currently support its use for sepsis prevention in this population (Manapurath et al., 2022)
But by promoting the repair of damaged myelin, it addresses one of the most devastating consequences of the disease
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Bacterial Contamination: This is the most obvious and dangerous risk
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