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Outcome measures included in trials to establish disease modification should include disease state assessment over 510 years while temporarily off all confounding symptomatic treatments (i.e., DBS and PD medications) with both appropriate clinical scales (i.e., UPDRS) as well as more innovative biomarkers 8,10,45

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Pseudo-first-order kinetics were also detected using PfGrx C88S (SSG), the freshly glutathionylated dithiol variant of PfGrx 26 , as an oxidant (Fig

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