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The present prespecified analyses investigated the associations between SGLT2i use at baseline and any SGLT2i use during the trial on primary and secondary efficacy outcomes in participants randomized to receive oral semaglutide versus placebo

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Plasma glucose level is predictive of serum ammonia level after retrograde occlusion of portosystemic shunts

Orforglipron (Foundayo) launched April 1, 2026 at $149-$299 a month with no food or water restrictions and slightly better tolerability data on long-term use

Obesity is increasingly understood as a chronic condition, and the trial data reflect this

Understanding who benefits most helps set realistic expectations