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These reactions are the first two reactions in the pentose phosphate pathway, which provides an alternative to part of the pathway of glycolysis, yielding glyceraldehyde 3-phosphate and fructose 6-phosphate

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Some studies have shown small reductions in total cholesterol, LDL cholesterol, and triglycerides in certain patients, though these medications are not substitutes for statins when lipid-lowering therapy is indicated