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More serious but rare side effects include: Pancreatitis (inflammation of the pancreas) Gallbladder problems Changes in heart rate While these serious complications are uncommon, they underscore why these drugs require medical supervision

Efficacy and tolerability of tirzepatide, a dual glucosedependent insulinotropic peptide and glucagonlike peptide1 receptor agonist in patients with type 2 diabetes: a 12week, randomized, doubleblind, placebocontrolled study to evaluate different doseescalation regimens

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Conclusion The evidence supports a nuanced conclusion regarding GLP-1 agonists for obesity in non-diabetic patients: they represent a significant therapeutic advance with game-changing potential currently limited by practical implementation challenges

Rahim, J

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