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However, Minot, Murphy, and Whipple received the joint Nobel Prize for discovering a cure for a previously fatal disease of unknown cause in 1934, becoming the first Americans to be awarded the Nobel Prize in Physiology and Medicine

In practice, the human protocols that have emerged in clinical and sports medicine settings cluster in the range of 200 to 600 micrograms per day, sitting conservatively within that broader range

The second safety question is the supply chain

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if storage of reconstituted material is necessary, aliquot into single-use volumes and keep at -80 C to minimize freeze-thaw degradation