To name just a few: fatigue, breathlessness, dizziness, diarrhoea, dementia, depression, tachycardia, swollen and sore joints, blurred vision, pain and numbness (or burning) in hands and feet, sore muscles, sore tongue, inability to walk (later)
When reproducible physiology and biochemistry persist across years, modalities, and care settings, the question stops being is anything wrong? and becomes a governance one: Who owns the trigger for reevaluation when signals persist but dont fit a textbook pathway and where is that ownership documented so cases dont stall between handoffs
We therefore examined DNA methylation at the region corresponding to that differentially methylated in the womens DNA, located in the genes first intron (Fig S4B), and found it to be significantly more methylated in the ovaries of the DSS-treated group than in the controls (Fig
However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]
Elevated levels increase cardiovascular risk
Typically, the recommended dose for adults is 1000-5000 mcg of methyl cobalamin injected into a muscle or under the skin once daily or weekly, depending on the severity of the deficiency
