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In AD, along with amyloid and tau phosphorylation, there is an associated increase in inflammation/glial activation, a decrease in synaptic function, an increase in astrocyte activation, and a state of insulin resistance
The label also has a new Risk Evaluation and Mitigation Strategy (REMS) program that aims to mitigate the risk of complications (such as infection, bleeding, pain) due to improper insertion and removal of the device
It provides a base on which the amino acid chain can grow
Participants received single ascending doses (0.512 mg) or multiple ascending doses (0.512 mg weekly)
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