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[,,] While it is known that there are multiple adverse effects that are related to the use of EDTA, CaNa 2 EDTA is known to have fewer adverse effects compared to Na 2 EDTA and has become the general chelating agent for clinical use that is able to react with a wide variety of metal ions

They're prescription medications, completely legal when prescribed by a doctor

SD-436 (0.1 nM-40 M, 20 h) effectively reduces the levels of the mutated STAT3 protein (STAT3 K658R ) in a dose-dependent manner in the Pfeiffer cell line, with a DC 50 value of 2.5 nM [1]

A logical and interesting extension would be to see if the natural producer strains are inherently robust to stressful conditions which are better tolerated by GSH supplementation

Yes, rare cases have been reported

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