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Safe: Semaglutide has been extensively studied and has a good safety profile
A livello cutaneo, GHK-Cu stimola la produzione di collagene di tipo I, III e V da parte dei fibroblasti dermici, nonch la sintesi di proteoglicani (decorina) e glicosaminoglicani
These may include: Semaglutide Options: Compounded Semaglutide, Oral Semaglutide, Ozempic, and Wegovy
My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it
You have a provider who knows your history, adjusts your dose, manages your side effects, and holds you accountable
