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Science 349 , 540543 (2015)

Mol Ecol 28(13):31973207 Tanase DM, Gosav EM, Neculae E, Costea CF, Ciocoiu M, Hurjui LL, Tarniceriu CC, Floria M (2020) Hypothyroidism-induced nonalcoholic fatty liver disease (HIN): mechanisms and emerging therapeutic options

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PDH catalyzes the formation of acetyl coenzyme A, a crucial step in energy production, and, through acetyl-CoA, serves as a precursor for acetylcholine (ACh), which is vital for nerve signal transmission and muscle function since ACh acts on the communication between neurons and in the neuromuscular junction, as well as for myelin production in nerve cells (36, 39, 40)

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In summary, humanized zebrafish modelsparticularly using adult immunodeficient strainshave established mature protocols for transplantation, drug administration, and live imaging, providing a solid foundation for inflammatory disease research