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D-Ala (Pos 2): Blocks DPP-IV degradation

You thought they were going to make a weight-loss drug and I wasnt going to take it? she said during an episode of her podcast, per People

These changes reduce its binding affinity to IGF-binding proteins (IGFBPs), allowing for a longer half-life (up to 2030 hours) and increased bioavailability in plasma

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