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Furthermore, in the context of narcolepsy, Adderall is effective in reducing sudden attacks of daytime sleepiness, thereby enhancing the quality of life for those affected by this condition

Semaglutide fatigue and other side effects that suddenly disappear at a dose that previously caused them can also signal potency loss

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Other parameters, such as natural weight regain, event disutilities, and baseline CVD prevalence, had smaller impacts

SURMOUNT-5: The head-to-head trial Published in the New England Journal of Medicine in 2025, SURMOUNT-5 was the first randomised trial to directly compare tirzepatide (Mounjaro) with semaglutide (Wegovy) at equivalent maximum doses in adults with obesity without type 2 diabetes