First, cysteine and glutamate are combined by gamma-glutamyl cysteinyl synthetase
Weight loss : While not the original purpose of these medications, many patients experience significant and sustained weight lossespecially those on higher-dose versions like Wegovy or Zepbound
In our earlier GLP-1 Insight Drop, we showed how the 2021 approval of Wegovy catalyzed a step-change in metabolic R&Dso much so that GLP-1 programs now account for 159 out of 426 active metabolic programs (~40%), effectively lifting the entire category
Simpson H, Savine R, Snksen P, Bengtsson B-A, Carlsson L, Christiansen JS, Clemmons D, Cohen P, Hintz R, Ho K, Mullis P, Robinson I, Strasburger C, Tanaka T, Thorner M
Disruptions in mitochondrial function lead to increased oxidative stress, cellular damage, and eventual neurodegeneration (Anderson et al., 2023)
They're not proof something doesn't work they're a reason to keep expectations modest and timelines realistic