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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

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A decrease in the level of GLP-1R contributes to neurotoxicity mediated by microglia and astrocytes, exacerbating neuron death and convulsive activity [74]

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