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Distinct proteomic and post-translational impacts of class-defining AML alterations To explore the imprint of recurrent genetic alterations on the AML proteome, we linked common genetic alterations to differences in the abundance of proteins and PTMs (Methods)

Genomic Regulation: It resets the gene expression of the Ubiquitin-Proteasome System (UPS), enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes)

535 HDAC-3 negatively regulates PPAR- signaling, causing signaling disruption, altering glucose homeostasis, and increasing hepatic glucose and lipid metabolism

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