Following more than twenty years of advancement, RNA therapeutics has materialized as a clinical reality, with enhancements in the design and chemistry of siRNAs, ASOs, and mRNAs attaining adequate stability, immune evasion, and therapeutic efficacy, while delivery technologies have progressed through effective, biocompatible materials and high-throughput screening
Since IGF-1 is also related to energy metabolism and body weight 32 , our current findings are consistent with former observations concerning BMI and adipokines as well as the findings on retinol binding protein (RBP)4 and the prognosis of ALS 3,19,33
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doi:10.3389/fphar.2025.1551843
daily) Presence of GI symptoms (nausea, vomiting, abdominal pain, constipation)