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Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly

A critically appraised topic

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Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated average reductions in body weight exceeding 20% over 48 weeks in some participants

Engler, A

* Seek immediate medical attention if you experience symptoms of a severe allergic reaction