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meningitidis ) in febrile children with and without acute respiratory infection (ARI) of the upper (URTI) or lower tract demonstrated that carriage of M

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Interestingly, some drugs are not completely metabolized or some metabolites are still excreted in the original form after many complex steps (Molet et al., 1997), activation ( FIGURE 1 Phase I metabolism pathway A series of reactions of most drugs occurs under the specific enzymes catalyze, which lead to structure and physicochemical properties changed (Iyanagi, 2007)