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Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor-1a (GHSR-1a)

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Furthermore, acupoint stimulation regulates the silent information regulator 1/forkhead box protein O1 pathway, inhibiting reactive oxygen species (ROS) -induced oxidative stress and reducing the expression of NOXs, ROS, and pro-inflammatory markers, thereby delaying cellular aging and exerting anti-inflammatory analgesic effects [156,157,158]

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