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1 There are lots of animal studies. Animal studies are useful for mechanism and early safety signals, but they do not prove that a treatment works in humans

Primary murine PDAC cells were derived from Kras tm1Tyj : Kras LSL-G12D/+ + Trp53 tm1Brn : Trp53 fl/fl + Ptf1a tm1(Cre)Hnak : Ptf1a Cre-ex1/+ (KPC) compound mutant mouse tumors and were prepared as fragments for outgrowth culture

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Functional expression of the rat pancreatic islet glucose-dependent insulinotropic polypeptide receptor: ligand binding and intracellular signaling properties

While research indicates that it does not significantly impact growth hormone levels, IGF-1, or glucose metabolism, long-term studies on its safety are still limited