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The third pathway also involves the addition of a highly water-soluble molecule (glutathione)

Semaglutide mimics the naturally occurring GLP-1 hormone, which regulates appetite, slows gastric emptying, and enhances insulin secretion in response to meals

Glutathione steps in to reduce oxidative stress, thereby mitigating the risk of autoimmune diseases like lupus, celiac disease, and rheumatoid arthritis

This might help cells resist oxidative stress better [24]

Both the LEADER (liraglutide) and SUSTAIN-6 (subcutaneous semaglutide) trials reported significant reductions in the primary outcome (incidence of MACE)

Accessed 11/25/2022, Themann CL, Masterson EA