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Early use of combination therapy may be considered, as the Vildagliptin Efficacy in combination with metfoRmIn for earlY treatment of type 2 diabetes (VERIFY) trial findings suggest that this approach provides superior and more durable effects on blood glucose levels than metformin monotherapy in people with both early-onset (age 150 min/week of moderate- to vigorous-intensity aerobic activity) and be encouraged to reduce sedentary time and break up sitting time with frequent activity breaks

Conversely, GT has been demonstrated to have pro-oxidant effects

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The key context for this comparison is that both compounds are strictly preclinical -- all claims about cognitive effects are based on animal models, and the translation of these findings to human cognition is uncertain

Endogenous presence in the brain DSIP-like immunoreactivity has been reported in mammalian brain tissue and in peripheral tissues, and its distribution was surveyed in Graf and Kastins review of the field