Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)
GLP-1 therapies reduced inflammatory markers and protected kidney function in animals and humans, including in the FLOW trial
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Weight loss typically becomes measurable by weeks four through eight
In conclusion, GLP-1RAs promoted macrophage polarization towards the M2 type, improving the inflammatory microenvironment of the synovium, maintaining synovial homeostasis, and inhibiting the progression of RA