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Tirzepatide targets two receptors, GLP-1 and GIP, and pushes weight loss to about 20-22%

Genetic studies have identified mutations in several genes, including LRRK2, SNCA, and PINK1 [8, 10, 11], which play critical roles in the pathogenesis of PD

Patients pairing GLP-1 therapy with HRT may experience: Greater total weight and fat loss compared to GLP-1 therapy alone Improved body composition and muscle tone Enhanced energy and daily performance More consistent, lasting results Clinical insights suggest that addressing hormonal imbalances alongside GLP-1 therapy may lead to up to 30% greater weight loss in appropriate candidates

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Risks of Switching From Semaglutide to Tirzepatide Adverse Effects : Both medications may have commonly reported side effects which are generally gastrointestinal disturbances (nausea, vomiting, diarrhea, stomach upset) and injection-site reactions (1,2,4,5)