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GLP-1 anti-obesity drugs lead to substantial weight loss in the real world March 25, 2024 We know that the GLP-1 anti-obesity drugs lead to substantial weight loss in clinical trials

In APP/PS1 mice, the cognitive improvement observed after ip administration of liraglutide was accompanied by decreased activation of microglia [66]

In contrast, a pooled analysis of clinical trials reporting separate CV events rates in patients with T2D and CKD did not find GLP1-RA to be associated with a reduction in composite CV event rates [76]

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The mechanism makes physiological sense

This is consistent with previous studies providing evidence for hypothalamic control of sympathetic pre-autonomic neurons in the PVN 26 through the use of the same GABA A receptor antagonist 52