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The fact that GLP-1R agonists have beneficial effects on both energy and glucose metabolism places this class of pharmacotherapies at a superior level compared to other drugs used to treat T2DM that cause weight gain

Appl Physiol Nutr Metab (2015) 40(11):112936

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

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People may microdose GLP-1 medications for many reasons, including: They have hit their target weight goal They have concerns about the cost of the medications They are sensitive to the side effects of the medications They want to just suppress their appetite They are worried about the supply of the medications Microdosing GLP-1 medications can come with real risks, including: Inaccurate doses Reduced effectiveness Unpredictable outcomes Possibility of regaining weight No data on the long-term effects of microdosing Minimal oversight Large clinical trials have confirmed that the standard GLP-1 doses work well when helping people lose weight and manage Type 2 diabetes