Research indicates that Traditional Chinese Medicine (TCM) extracts (e.g., terpenoids, phenols, flavonoids, saponins, and alkaloids) can directly activate AMPK or regulate its upstream kinases (LKB1, CaMKK ) and downstream effectors (SIRT1, PPAR , Nrf2), thereby improving hepatic lipid accumulation, mitigating inflammatory damage, and delaying NAFLD progression
Taken together, lactylation exerts a phase-dependent role in ischemiareperfusion injury: detrimental during ischemia by promoting calcium overload and mitochondrial dysfunction, yet potentially protective after reperfusion when lactate acts independently of lactylation
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It is widely accepted that alcohol use and a number of pharmacological agents, for example isoniazid, induce expression of CYP2E1 (see section Potential drug interactions with paracetamol metabolism and section Alcohol use)
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