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Reduced levels of glutathione in these diseases may improve the sensitivity of cells to oxidative stress, thereby damaging cellular functions ( Generally, glutathione, serving as the major antioxidant inside cells, not only directly erasing free radicals but also remains oxidative balance within cells by various mechanisms, which is crucial for keeping cellular health

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JAD 63, 13371346

(Article in Japanese) Kuwasawa-Iwasaki M, Io H, Muto M, et al

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The sensorineural deafness in type 4 Bartter syndrome is due to the loss of ClC-Ka and ClC-Kb function in the inner ear