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Sem Liver Dis

Diabetologia (1995) 38(7):7536

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Impaired glucose tolerance has been reported in 21-64% at diagnosis and diabetes mellitus in 20-47% ( Figure 1 Table 1 Metabolic effects of insulin and alterations in Cushings disease and acromegaly

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Poor glycemic control can affect kidney function over time, while some diabetes medicationsincluding insulin (which can cause edema regardless of formulation, particularly after initiation or dose intensification) and thiazolidinedionesare known to cause fluid retention