glp-1 liver fibrosis Pioglitazone with SGLT2 inhibitors or receptor agonists in patients with type 2 diabetes and non-alcoholic fatty disease: could the combinations of an old friend with new players yield better outcomes? glp-1 liver toxicity The future

147157 (Springer Berlin Heidelberg, 2011)

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What are safer alternatives to unregulated GLP-1 drugs

Overall, preclinical and clinical data align in demonstrating CV protective effects of GLP-1RAs particularly with respect to vascular protection and heart failure (predominantly HFpEF), while some uncertainties remain regarding the magnitude of benefit on HFrEF-related endpoints and the specific mechanistic pathways involved

Tip: Aim for at least 2535g of fiber daily, with an emphasis on fermentable fibers

GLP-1 receptor agonists mimic GLP-1, lowering blood glucose by stimulating insulin secretion, slowing gastric emptying, and decreasing glucagon release 13