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Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

Natural GLP-1 has a very short half-life of approximately 2 to 3 minutes because it is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4)

Critical considerations for bodybuilders Muscle loss: GLP-1-class compounds can cause muscle loss if sufficient protein is not consumed (~2 g per kg body weight) and resistance training is not performed

Annual sales of GLP-1 based drugs are expected to overtake the US$ 100 billion mark by 2029 (Park)

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Nonetheless, these clinical trials were underpowered to detect rare events such as suicidal ideation and self-injurious behavior, and they systematically excluded patients with psychiatric comorbidities commonly seen in clinical settings