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For instance, LDHA has been demonstrated to promote tumor cell survival by mitigating oxidative stress, whereas LDHB deficiency induces mitochondrial dysfunction and oxidative damage, ultimately leading to neurodegeneration in the adult mouse brain (46,47)

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129,130 Nutritional supplementation of NAD precursors may reduce insulin resistance during obesity and aging 80,102 and references therein)

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[3] Carnitine supplements do not seem to improve oxygen consumption or metabolic functions when exercising, nor do they increase the amount of carnitine in muscle